Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
1998 5
1999 2
2000 8
2001 11
2002 11
2003 3
2004 14
2005 9
2006 4
2007 3
2008 10
2009 5
2010 4
2011 4
2012 1
2013 3
2014 3
2015 1
2017 2
2018 2
2019 1
2020 2
2021 3
2022 2
2023 5
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

112 results

Results by year

Filters applied: . Clear all
Page 1
CEP-1347 Targets MDM4 Protein Expression to Activate p53 and Inhibit the Growth of Glioma Cells.
Mitobe Y, Nakagawa-Saito Y, Togashi K, Suzuki S, Sugai A, Matsuda KI, Sonoda Y, Kitanaka C, Okada M. Mitobe Y, et al. Anticancer Res. 2022 Oct;42(10):4727-4733. doi: 10.21873/anticanres.15977. Anticancer Res. 2022. PMID: 36192008
However, it remains unknown whether CEP-1347 acts as an MDM4 inhibitor and as such activates p53 in other types of human cancer cells. ...Trypan blue dye exclusion was used to examine the effect of CEP-1347 on cell growth. RESULTS: CEP-1347 …
However, it remains unknown whether CEP-1347 acts as an MDM4 inhibitor and as such activates p53 in other types of human cance …
ACS chemical neuroscience spotlight on CEP-1347.
Sweeney ZK, Lewcock JW. Sweeney ZK, et al. ACS Chem Neurosci. 2011 Jan 19;2(1):3-4. doi: 10.1021/cn1000793. Epub 2010 Sep 3. ACS Chem Neurosci. 2011. PMID: 22778853 Free PMC article. Review. No abstract available.
CEP-1347 Dually Targets MDM4 and PKC to Activate p53 and Inhibit the Growth of Uveal Melanoma Cells.
Togashi K, Suzuki S, Mitobe Y, Nakagawa-Saito Y, Sugai A, Takenouchi S, Sugimoto M, Kitanaka C, Okada M. Togashi K, et al. Cancers (Basel). 2023 Dec 25;16(1):118. doi: 10.3390/cancers16010118. Cancers (Basel). 2023. PMID: 38201546 Free PMC article.
We also examined the impact of CEP-1347 on the protein kinase C (PKC) pathway, known to play a pivotal role in UM cell growth. High-grade UM cell lines were used to analyze the effects of genetic and pharmacological inhibition of MDM4 and PKC, respectively, as well …
We also examined the impact of CEP-1347 on the protein kinase C (PKC) pathway, known to play a pivotal role in UM cell growth. …
CEP-1347 (Cephalon).
Mucke HA. Mucke HA. IDrugs. 2003 Apr;6(4):377-83. IDrugs. 2003. PMID: 12789610 Review. No abstract available.
Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.
Maroney AC, Finn JP, Connors TJ, Durkin JT, Angeles T, Gessner G, Xu Z, Meyer SL, Savage MJ, Greene LA, Scott RW, Vaught JL. Maroney AC, et al. J Biol Chem. 2001 Jul 6;276(27):25302-8. doi: 10.1074/jbc.M011601200. Epub 2001 Apr 26. J Biol Chem. 2001. PMID: 11325962 Free article.
In an effort to identify molecular target(s) of CEP-1347 in the JNK cascade, JNK1 and known upstream regulators of JNK1 were co-expressed in Cos-7 cells to determine whether CEP-1347 could modulate JNK1 activation. ...These results identify MLKs as tar …
In an effort to identify molecular target(s) of CEP-1347 in the JNK cascade, JNK1 and known upstream regulators of JNK1 were c …
The Novel MDM4 Inhibitor CEP-1347 Activates the p53 Pathway and Blocks Malignant Meningioma Growth In Vitro and In Vivo.
Mitobe Y, Suzuki S, Nakagawa-Saito Y, Togashi K, Sugai A, Sonoda Y, Kitanaka C, Okada M. Mitobe Y, et al. Biomedicines. 2023 Jul 12;11(7):1967. doi: 10.3390/biomedicines11071967. Biomedicines. 2023. PMID: 37509605 Free PMC article.
The growth inhibitory effects of CEP-1347 were examined in vitro and in a mouse xenograft model of meningioma. ...Our findings suggest targeting the p53 pathway with CEP-1347 represents a novel and viable approach to treating aggressive meningiomas....
The growth inhibitory effects of CEP-1347 were examined in vitro and in a mouse xenograft model of meningioma. ...Our findings …
Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases.
Saporito MS, Hudkins RL, Maroney AC. Saporito MS, et al. Prog Med Chem. 2002;40:23-62. doi: 10.1016/s0079-6468(08)70081-x. Prog Med Chem. 2002. PMID: 12516522 Review.
In particular, preclinical data will be presented on the c-Jun Amino Kinase pathway inhibitor, CEP-1347/KT-7515, with respect to it's properties that make it a desirable clinical candidate for treatment of various neurodegenerative diseases....
In particular, preclinical data will be presented on the c-Jun Amino Kinase pathway inhibitor, CEP-1347/KT-7515, with respect …
Antagonizing MDM2 Overexpression Induced by MDM4 Inhibitor CEP-1347 Effectively Reactivates Wild-Type p53 in Malignant Brain Tumor Cells.
Mitobe Y, Suzuki S, Nakagawa-Saito Y, Togashi K, Sugai A, Sonoda Y, Kitanaka C, Okada M. Mitobe Y, et al. Cancers (Basel). 2023 Aug 30;15(17):4326. doi: 10.3390/cancers15174326. Cancers (Basel). 2023. PMID: 37686602 Free PMC article.
The growth inhibitory effects of CEP-1347 alone or in combination with MDM2 on inhibition were examined by dye exclusion and/or colony formation assays. The treatment of malignant brain tumor cell lines with CEP-1347 markedly increased MDM2 protein exp …
The growth inhibitory effects of CEP-1347 alone or in combination with MDM2 on inhibition were examined by dye exclusion and/o …
CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo.
Saporito MS, Brown EM, Miller MS, Carswell S. Saporito MS, et al. J Pharmacol Exp Ther. 1999 Feb;288(2):421-7. J Pharmacol Exp Ther. 1999. PMID: 9918541
We have identified a bis-ethylthiomethyl analog of K-252a, CEP-1347/KT-7515, that promotes neuronal survival in culture and in vivo. ...CEP-1347/KT-7515 did not inhibit monoamine oxidase B or the dopamine transporter, suggesting that the neuroprotectiv …
We have identified a bis-ethylthiomethyl analog of K-252a, CEP-1347/KT-7515, that promotes neuronal survival in culture and in …
Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients.
Ma Q, Gelbard HA, Maggirwar SB, Dewhurst S, Gendelman HE, Peterson DR, DiFrancesco R, Hochreiter JS, Morse GD, Schifitto G. Ma Q, et al. J Neurovirol. 2013 Jun;19(3):254-60. doi: 10.1007/s13365-013-0172-z. Epub 2013 Jun 5. J Neurovirol. 2013. PMID: 23737347 Free PMC article.
CEP-1347 and atazanavir pharmacokinetics were determined when CEP-1347 50 mg twice daily was administered to HIV-infected patients (n = 20) receiving combination antiretroviral therapy including atazanavir and ritonavir (ATV/RTV, 300/100 mg) once daily …
CEP-1347 and atazanavir pharmacokinetics were determined when CEP-1347 50 mg twice daily was administered to HIV …
112 results