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Grapefruit is a citrus fruit. People use the fruit, oil from the peel, and extracts from the seed as medicine. Grapefruit seed extract is processed from grapefruit seeds and pulp obtained as a byproduct from grapefruit juice production. Vegetable glycerin is added to the final product to reduce acidity and bitterness.
Grapefruit juice is used for asthma, high cholesterol, "hardening of the arteries" (atherosclerosis), cancer, improving levels of red blood cells, a skin disease called psoriasis, and for weight loss and obesity. It is also used to reduce stomach complaints in people with eczema (atopic dermatitis).
Grapefruit seed extract is taken by mouth for bacterial, viral, and fungal infections including yeast infections.
Grapefruit oil is applied to the skin for tired muscles, hair growth, toning the skin, and for acne and oily skin. It is also used for the common cold, flu (influenza), and swine flu.
Grapefruit seed extract is applied to the skin as a facial cleanser, first-aid treatment, remedy for mild skin irritations, and as a vaginal douche for vaginal yeast infections (candidiasis). It is also used as an ear or nasal rinse for preventing and treating infections; as a gargle for sore throats; in a shampoo to treat lice; as a dental rinse for preventing gingivitis and promoting healthy gums; and as a breath freshener.
Some people inhale grapefruit vapors to help the body retain water, for headache, stress, and depression. Grapefruit seed extract vapor has also been inhaled for the treatment of lung infections.
In food and beverages, grapefruit is consumed as a fruit, juice, and is used as a flavoring component.
In manufacturing, grapefruit oil and seed extract are used as a fragrance component in soaps and cosmetics; and as a household cleaner for fruits, vegetables, meats, kitchen surfaces, dishes, and others.
In agriculture, grapefruit seed extract is used to kill bacteria and fungus, fight mold growth, kill parasites in animal feeds, preserve food and disinfect water.
It's important to remember that drug interactions with grapefruit juice are well documented. The chemistry of the grapefruit varies by the species, the growing conditions, and the process used to extract the juice. Before adding grapefruit to your diet or your list of natural medicines, check with your healthcare provider if you take medications.
How does work?
Grapefruit is a source of vitamin C, fiber, potassium, pectin, and other nutrients. Some components might have antioxidant effects that might help protect cells from damage or reduce cholesterol.
It is not clear how the oil might work for medicinal uses.
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Vitamin D Deficiency: How Much Vitamin D Is Enough? See SlideshowInsufficient Evidence to Rate Effectiveness for...
- Asthma. Some research shows that eating vitamin C-rich citrus fruits, including grapefruit and others, might improve lung function in people with asthma. But other studies have not shown this benefit.
- Eczema (atopic dermatitis). Early research shows that a grapefruit seed extract (ParaMicrocidin, Allergy Research Group) can decrease constipation, gas, and stomach discomfort in people with eczema. This benefit may be due to the effect of grapefruit on intestinal bacteria.
- High cholesterol. Early research suggest that taking grapefruit pectin daily for 16 weeks decreases total cholesterol and the ratio of low-density lipoprotein (LDL or "bad") cholesterol to high-density lipoprotein (HDL or "good") cholesterol compared to baseline.
- High blood fats called triglycerides. Eating one grapefruit per day appears to reduce total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride levels in people with high triglyceride levels.
- Lice. Early research shows that applying a shampoo containing grapefruit extract (Licatack shampoo) to the hair of children for 10-20 minutes kills lice. Applying the shampoo again 10 days later helps remove any remaining nits (91417).
- Weight loss. Early research suggests that eating fresh grapefruit daily increases weight loss in overweight people.
- Hardening of the arteries (atherosclerosis).
- Preventing cancer.
- Psoriasis.
- Muscle tiredness.
- Promoting hair growth.
- Toning the skin.
- Reducing acne and oily skin.
- Treating headaches.
- Stress.
- Depression.
- Infections.
- Digestive complaints in people with eczema.
- Yeast infections (as a vaginal douche).
- Other conditions.
Grapefruit is LIKELY SAFE in the amounts normally used as food and POSSIBLY SAFE when taken by mouth for medicinal purposes.
Grapefruit is POSSIBLY UNSAFE when taken by mouth in high amounts. If you take any medications, check with your healthcare provider before adding grapefruit to your diet or using it as a medicine. Grapefruit interacts with a long list of medications (see "Are there any interactions with medications?" below).
Pregnancy and breast-feeding: Not enough is known about the use of grapefruit during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Breast cancer: There is concern about the safety of drinking excessive amounts of grapefruit juice. Some research suggests that postmenopausal women who consume a quart or more of grapefruit juice every day have a 25% to 30% increased chance of developing breast cancer. Grapefruit juice decreases how estrogen is broken down in the body and might increase estrogen levels in the body. More research is needed to confirm these findings. Until more is known, avoid drinking excessive amounts of grapefruit juice, especially if you have breast cancer or are at higher than usual risk for developing breast cancer.
Diseases of the heart muscle: Consuming grapefruit juice might increase the potential for abnormal heart rhythm. People with these diseases should consume grapefruit juice in moderation.
Hormone sensitive cancers and conditions: Consuming large amounts of grapefruit might increase hormone levels and therefore increase the risk of hormone sensitive conditions. Women with hormone sensitive conditions should avoid grapefruit.
Amiodarone (Cordarone)Interaction Rating: Major Do not take this combination.
Grapefruit juice can increase how much amiodarone (Cordarone) the body absorbs. Drinking grapefruit juice while taking amiodarone (Cordarone) might increase the effects and side effects. Avoid drinking grapefruit juice if you are taking amiodarone (Cordarone).
Artemether (Artenam, Paluther)Interaction Rating: Major Do not take this combination.
The body breaks down artemether (Artenam, Paluther) to get rid of it. Grapefruit juice can decrease how quickly the body breaks down artemether (Artenam, Paluther). Drinking grapefruit juice while taking artemether (Artenam, Paluther) might increase the effects and side effects of artemether (Artenam, Paluther). Do not drink grapefruit juice if you are taking artemether (Artenam, Paluther).
Atorvastatin (Lipitor)Interaction Rating: Major Do not take this combination.
Atorvastatin (Lipitor) is a type of cholesterol lowering medication known as a "statin." The body breaks down some "statins" to get rid of them. Grapefruit juice might decrease how quickly the body breaks down "statins" including atorvastatin (Lipitor). Drinking grapefruit juice while taking atorvastatin (Lipitor) or other "statins" might increase the effects and side effects of these medications.
Grapefruit might interact with some "statins" including lovastatin (Mevacor), simvastatin (Zocor), and atorvastatin (Lipitor). Grapefruit juice does not interact with other "statins" including pravastatin (Pravachol), fluvastatin (Lescol), and rosuvastatin (Crestor).
Buspirone (BuSpar)Interaction Rating: Major Do not take this combination.
Grapefruit juice might increase how much buspirone (BuSpar) the body absorbs. Drinking grapefruit juice while taking buspirone (BuSpar) might increase the effects and side effects of buspirone (BuSpar).
Carbamazepine (Tegretol)Interaction Rating: Major Do not take this combination.
Grapefruit juice might increase how much carbamazepine (Tegretol) the body absorbs. Drinking grapefruit juice while taking carbamazepine (Tegretol) might increase the effects and side effects of carbamazepine (Tegretol).
Carvedilol (Coreg)Interaction Rating: Major Do not take this combination.
The body breaks down carvedilol (Coreg) to get rid of it. Grapefruit juice seems to decrease how quickly the body breaks down carvedilol (Coreg). Drinking grapefruit juice while taking carvedilol (Coreg) might increase the effects and side effects of carvedilol (Coreg).
Celiprolol (Celicard)Interaction Rating: Major Do not take this combination.
Grapefruit appears to decrease how much celiprolol (Celicard) is absorbed. This might decrease the effectiveness of celiprolol (Celicard). Separating administration of celiprolol (Celicard) and consumption of grapefruit by at least 4 hours.
Cisapride (Propulsid)Interaction Rating: Major Do not take this combination.
Grapefruit juice might decrease how quickly the body gets rid of cisapride (Propulsid). Drinking grapefruit juice while taking cisapride (Propulsid) might increase the effects and side effects of cisapride (Propulsid).
Clomipramine (Anafranil)Interaction Rating: Major Do not take this combination.
The body breaks down clomipramine (Anafranil) to get rid of it. Grapefruit juice might decrease how quickly the body gets rid of clomipramine (Anafranil). Taking grapefruit juice along with clomipramine (Anafranil) might increase the effects and side effects of clomipramine (Anafranil).
Clopidogrel (Plavix)Interaction Rating: Major Do not take this combination.
Clopidogrel (Plavix) is a prodrug. Prodrugs need to be activated by the body to work. Grapefruit appears to decrease how much clopidogrel (Plavix) is activated by the body. This might lead to a decreased efficacy of clopidogrel. Do not take grapefruit with clopidogrel.
Cyclosporine (Neoral, Sandimmune)Interaction Rating: Major Do not take this combination.
Grapefruit might increase how much cyclosporine (Neoral, Sandimmune) the body absorbs. Drinking grapefruit juice while taking cyclosporine (Neoral, Sandimmune) might increase the side effects of cyclosporine.
Dextromethorphan (Robitussin DM, and others)Interaction Rating: Major Do not take this combination.
The body breaks down dextromethorphan (Robitussin DM, others) to get rid of it. Grapefruit might decrease how quickly the body breaks down dextromethorphan (Robitussin DM, others). Drinking grapefruit juice while taking dextromethorphan (Robitussin DM, others) might increase the effects and side effects of dextromethorphan (Robitussin DM, others).
EstrogensInteraction Rating: Major Do not take this combination.
The body breaks down estrogens to get rid of them. Grapefruit juice seems to decrease how quickly the body breaks down estrogens and increase how much estrogen the body absorbs. Drinking grapefruit juice while taking estrogens might increase estrogen levels and side effects associated with estrogen such as breast cancer.
Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol (Climara, Vivelle, Estring), and others.
Etoposide (VePesid)Interaction Rating: Major Do not take this combination.
Grapefruit might decrease how much etoposide (VePesid) the body absorbs. Drinking grapefruit juice while taking etoposide (VePesid) might decrease the effectiveness of etoposide (VePesid). To avoid this interaction, separate taking this medication from consuming grapefruit by at least 4 hours.
HalofantrineInteraction Rating: Major Do not take this combination.
The body breaks down halofantrine to get rid of it. Grapefruit juice seems to decrease how quickly the body breaks down halofantrine. Drinking grapefruit juice while taking halofantrine might increase halofantrine levels and side effects associated with halofantrine, including abnormal heartbeat.
Lovastatin (Mevacor)Interaction Rating: Major Do not take this combination.
Lovastatin (Mevacor) is a type of cholesterol lowering medication known as a "statin." The body breaks down some "statins" to get rid of them. Grapefruit juice might decrease how quickly the body breaks down "statins" including lovastatin (Mevacor). Drinking grapefruit juice while taking lovastatin (Mevacor) or other "statins" might increase the effects and side effects of these medications.
Grapefruit might interact with some "statins" including lovastatin (Mevacor), simvastatin (Zocor), and atorvastatin (Lipitor). Grapefruit juice does not interact with other "statins" including pravastatin (Pravachol), fluvastatin (Lescol), and rosuvastatin (Crestor).
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)Interaction Rating: Major Do not take this combination.
Some medications are changed and broken down by the liver. Grapefruit juice might decrease how quickly the liver breaks down some medications. Drinking grapefruit juice while taking some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking grapefruit, talk to your healthcare provider if you are taking any medications that are changed by the liver.
Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.
Medications for high blood pressure (Calcium channel blockers)Interaction Rating: Major Do not take this combination.
Grapefruit juice might increase how much medication for high blood pressure the body absorbs. Drinking grapefruit juice while taking some medications for high blood pressure might cause your blood pressure to go too low.
Some medications for high blood pressure include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others.
Medications moved by pumps in cells (Organic anion-transporting polypeptide substrates)Interaction Rating: Major Do not take this combination.
Some medications are moved by pumps in cells. Grapefruit might change how these pumps work and decrease how much of some medications get absorbed by the body. This could make these medications less effective. To avoid this interaction, separate taking these medications from consuming grapefruit by at least 4 hours.
Some of these medications that are moved by pumps in cells include bosentan (Tracleer), celiprolol (Celicard, others), etoposide (VePesid), fexofenadine (Allegra), fluoroquinolone antibiotics, glyburide (Micronase, Diabeta), irinotecan (Camptosar), methotrexate, paclitaxel (Taxol), saquinavir (Fortovase, Invirase), rifampin, statins, talinolol, torsemide (Demadex), troglitazone, and valsartan (Diovan).
MethylprednisoloneInteraction Rating: Major Do not take this combination.
The body breaks down methylprednisolone to get rid of it. Grapefruit juice can decrease how quickly the body gets rid of methylprednisolone. Drinking grapefruit juice while taking methylprednisolone might increase the effects and side effects of methylprednisolone.
Pitavastatin (Pravachol)Interaction Rating: Major Do not take this combination.
Pitavastatin (Pravachol) is a type of cholesterol lowering medication known as a "statin." The body breaks down some "statins" to get rid of them. Grapefruit juice might decrease how quickly the body breaks down "statins" including pitavastatin (Pravachol). Drinking grapefruit juice while taking pitavastatin (Pravachol) or other "statins" might increase the effects and side effects of these medications.
Grapefruit might interact with some "statins" including lovastatin (Mevacor), simvastatin (Zocor), and atorvastatin (Lipitor). Grapefruit juice does not interact with other "statins" including pravastatin (Pravachol), fluvastatin (Lescol), and rosuvastatin (Crestor).
Praziquantel (Biltricide)Interaction Rating: Major Do not take this combination.
The body breaks down praziquantel (Biltricide) to get rid of it. Grapefruit juice can decrease how quickly the body breaks down praziquantel (Biltricide). Drinking grapefruit juice while taking praziquantel (Biltricide) might increase the effects and side effects of praziquantel (Biltricide).
QuinidineInteraction Rating: Major Do not take this combination.
The body breaks down quinidine to get rid of it. Grapefruit juice might decrease how fast the body gets rid of quinidine. Drinking grapefruit juice while taking quinidine might increase the chance of side effects.
Scopolamine (Transderm Scop)Interaction Rating: Major Do not take this combination.
The body breaks down scopolamine to get rid of it. Grapefruit juice can decrease how fast the body breaks down scopolamine. Drinking grapefruit juice while taking scopolamine might increase the effects and side effects of scopolamine.
Sedative medications (Benzodiazepines)Interaction Rating: Major Do not take this combination.
Sedative medications can cause sleepiness and drowsiness. Grapefruit juice can decrease how quickly the body breaks some sedative medications. Drinking grapefruit juice while taking some sedative medications can increase the effects and side effects of some sedative medications.
Some sedative medications (benzodiazepines) that might interact with grapefruit juice include diazepam (Valium), midazolam (Versed), quazepam (Doral), and triazolam (Halcion).
Sildenafil (Viagra)Interaction Rating: Major Do not take this combination.
The body breaks down sildenafil (Viagra) to get rid of it. Grapefruit can decrease how quickly the body breaks down sildenafil (Viagra). Drinking grapefruit juice while taking sildenafil (Viagra) can increase the effects and side effects of sildenafil (Viagra).
Simvastatin (Zocor)Interaction Rating: Major Do not take this combination.
Simvastatin (Zocor) is a type of cholesterol lowering medication known as a "statin." The body breaks down some "statins" to get rid of them. Grapefruit juice might decrease how quickly the body breaks down "statins" including simvastatin (Zocor). Drinking grapefruit juice while taking simvastatin (Zocor) or other "statins" might increase the effects and side effects of these medications.
Grapefruit might interact with some "statins" including lovastatin (Mevacor), simvastatin (Zocor), and atorvastatin (Lipitor). Grapefruit juice does not interact with other "statins" including pravastatin (Pravachol), fluvastatin (Lescol), and rosuvastatin (Crestor).
Terfenadine (Seldane)Interaction Rating: Major Do not take this combination.
Grapefruit can increase how much terfenadine (Seldane) that the body absorbs. Drinking grapefruit juice while taking terfenadine (Seldane) might increase the effects and side effects of terfenadine (Seldane).
Ticagrelor (Brilinta)Interaction Rating: Major Do not take this combination.
The body breaks down ticagrelor (Brilinta) to get rid of it. Grapefruit can decrease how quickly the body breaks down ticagrelor (Brilinta). Drinking grapefruit juice while taking ticagrelor (Brilinta) can increase the effects and side effects of ticagrelor (Brilinta).
Aliskiren (Tekturna, Rasilez)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Aliskiren (Tekturna, Rasilez) is moved by pumps in cells in the body. Grapefruit might change how these pumps work and decrease how much aliskiren (Tekturna, Rasilez) gets absorbed by the body. This could make this medication less effective. To avoid this interaction, separate taking this medication from consuming grapefruit by at least 4 hours.
BUDESONIDE (Pulmicort)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down budesonide (Pulmicort) to get rid of it. Grapefruit might decease how quickly the body gets rid of budesonide (Pulmicort). Drinking grapefruit while taking budesonide (Pulmicort) might increase the side effects of budesonide (Pulmicort).
CaffeineInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down caffeine to get rid of it. Grapefruit might decease how quickly the body gets rid of caffeine. Drinking grapefruit while taking caffeine might increase the side effects of caffeine including jitteriness, headache, and a fast heartbeat.
ColchicineInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down colchicine to get rid of it. Grapefruit might decrease how quickly the body gets rid of colchicine. But some research shows that grapefruit does not decrease how quickly the body gets rid of colchicine. Until more is known, follow any instructions on the colchicine label related to intake of grapefruit.
ErythromycinInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down erythromycin to get rid of it. Grapefruit can decrease how quickly the body gets rid of erythromycin. Taking grapefruit juice along with erythromycin might increase the effects and side effects of erythromycin.
Fexofenadine (Allegra)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Grapefruit might decrease how much fexofenadine (Allegra) the body absorbs. Drinking grapefruit juice while taking fexofenadine (Allegra) might decrease the effectiveness of fexofenadine (Allegra). To avoid this interaction, separate taking this medication from consuming grapefruit by at least 4 hours.
Fluvoxamine (Luvox)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Grapefruit juice can increase how much fluvoxamine (Luvox) the body absorbs. Drinking grapefruit juice while taking fluvoxamine (Luvox) might increase the effects and side effects of fluvoxamine (Luvox).
Itraconazole (Sporanox)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Itraconazole (Sporanox) is used to treat fungal infections. Grapefruit juice might affect how much itraconazole (Sporanox) the body absorbs. But there is not enough information to know if this interaction is a major concern.
Levothyroxine (Synthroid, others)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Levothyroxine (Synthroid, others) is moved by pumps in cells in the body. Grapefruit might change how these pumps work and decrease how much levothyroxine (Synthroid, others) gets absorbed by the body. This could make this medication less effective. To avoid this interaction, separate taking this medication from consuming grapefruit by at least 4 hours.
Losartan (Cozaar)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The liver activates losartan (Cozaar) to make it work. Grapefruit juice might decrease how quickly the body activates losartan (Cozaar). Drinking grapefruit juice while taking losartan (Cozaar) might decrease the effectiveness of losartan.
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Some medications are changed and broken down by the liver. Grapefruit juice might decrease how quickly the liver breaks down some medications. Taking grapefruit juice along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking grapefruit juice talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include amitriptyline (Elavil), haloperidol (Haldol), ondansetron (Zofran), propranolol (Inderal), theophylline (Theo-Dur, others), verapamil (Calan, Isoptin, others), and others.
Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Some medications are changed and broken down by the liver. Grapefruit juice might decrease how quickly the liver breaks down some medications. Taking grapefruit juice along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking grapefruit juice talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include omeprazole (Prilosec), lansoprazole (Prevacid), and pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); and others.
Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Some medications are changed and broken down by the liver. Grapefruit juice might decrease how quickly the liver breaks down some medications. Taking grapefruit juice along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking grapefruit juice talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), and piroxicam (Feldene); celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); and others.
Methadone (Dolophine)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Grapefruit juice might increase how much methadone (Dolophine) the body absorbs. Drinking grapefruit juice while taking methadone (Dolophine) might increase the effects and side effects of methadone (Dolophine).
Nadolol (Corgard)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Nadolol (Corgard) is moved by pumps in cells in the body. Grapefruit might change how these pumps work and decrease how much nadolol (Corgard) gets absorbed by the body. This could make this medication less effective. However, some research shows that grapefruit does not affect how much nadolol (Corgard) gets absorbed by the body. Until more is known, follow any instructions on the nadolol (Corgard) label related to intake of grapefruit.
Nilotinib (Tasigna)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Grapefruit juice can increase how much Nilotinib (Tasigna) the body absorbs. Drinking grapefruit juice while taking Nilotinib (Tasigna) might increase the effects and side effects. Avoid drinking grapefruit juice if you are taking Nilotinib (Tasigna).
Oxycodone (Oxycontin)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down oxycodone (Oxycontin) to get rid of it. Grapefruit juice can decrease how quickly the body breaks down oxycodone (Oxycontin). Drinking grapefruit juice while taking oxycodone (Oxycontin) might increase the effects and side effects of Oxycodone (Oxycontin).
PrimaquineInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Grapefruit juice can increase how much primaquine is available in the body. It is unclear what effects this might have. Be cautious with this combination.
Saquinavir (Fortovase, Invirase)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Drinking grapefruit juice can increase how much saquinavir (Fortovase, Invirase) the body absorbs. Drinking grapefruit juice while taking saquinavir (Fortovase, Invirase) might increase the effects and side effects of saquinavir.
SertralineInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down sertraline to get rid of it. Grapefruit can decrease how quickly the body breaks down sertraline. Drinking grapefruit juice while taking sertraline can increase the effects and side effects of sertraline.
Sunitinib (Sutent)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down sunitinib (Sutent) to get rid of it. Grapefruit can decrease how quickly the body breaks down sunitinib (Sutent). Drinking grapefruit juice while taking sunitinib (Sutent) can increase the effects and side effects of sunitinib (Sutent). But some research shows that the effect of grapefruit on sunitinib (Sutent) is not a big concern. Until more is known, follow any instructions on the sunitinib (Sutent) label related to intake of grapefruit.
TacrolimusInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Drinking grapefruit juice might increase the concentration of tacrolimus in the blood. Drinking grapefruit juice while taking tacrolimus might increase the risk for side effects.
TalinololInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Grapefruit juice can reduce how much talinolol is available in the body. Drinking grapefruit juice with talinolol might reduce the effects of talinolol.
TheophyllineInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Drinking grapefruit juice might decrease the effects of theophylline. There's not enough information to know if this is a big concern.
Tolvaptan (Samsca)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
The body breaks down tolvaptan (Samsca) to get rid of it. Grapefruit can decrease how quickly the body breaks down tolvaptan (Samsca). Drinking grapefruit juice while taking tolvaptan (Samsca) can increase the effects and side effects of tolvaptan (Samsca).
Warfarin (Coumadin)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Warfarin (Coumadin) is used to slow blood clotting. Drinking grapefruit juice might increase the effects of warfarin (Coumadin) and increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.
Acebutolol (Sectral)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider.
Acebutolol (Sectral) is moved by pumps in cells in the body. Grapefruit might change how these pumps work and decrease how much acebutolol (Sectral) gets absorbed by the body. This could make this medication less effective. To avoid this interaction, separate taking this medication from consuming grapefruit by at least 4 hours.
Amprenavir (Agenerase)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider.
Grapefruit might slightly decrease how much amprenavir (Agenerase) is absorbed by the body. But this interaction is probably not a major concern.
The appropriate dose of grapefruit depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for grapefruit. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
QUESTION
Next to red peppers, you can get the most vitamin C from ________________. See AnswerNatural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
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