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The effect of resistance training on markers of immune function and inflammation in previously sedentary women recovering from breast cancer: a randomized controlled trial

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Abstract

The purpose of this randomized controlled trial was to determine the effects of resistance training (RT) on markers of inflammation and immune function in breast cancer survivors. Thirty-nine breast cancer survivors were randomly assigned to a RT (n = 20) or control (n = 19) group. RT performed supervized exercise three times per week. Natural killer cell (NK) and natural killer T-cell (NKT) function, and markers of inflammation (serum TNF-α, IL-6, IL-10, and CRP) were measured before and after training. Changes in NK and NKT cell function were analyzed using ANCOVA, with the change score the dependent variable, and the baseline value of the same variable the covariate. Effect sizes (ES) were calculated via partial eta-squared. We found a significant reduction, and large associated ESs, in the RT group compared to the control group for change in NK cell expression of TNF-α (p = 0.005, ES = 0.21) and NKT cell expression of TNF-α (p = 0.04, ES = 0.12). No differences were observed in any serum marker. Significant improvements in all measurements of strength were found in RT compared to control (p < 0.001; large ESs ranging from 0.32 to 0.51). These data demonstrate that RT has a beneficial effect on the NK and NKT cell expression of TNF-α indicating that RT may be beneficial in improving the inflammatory profile in breast cancer survivors.

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Acknowledgments

This study was supported by a grant from Western Sydney University, Australia.

Conflict of interest

All authors acknowledge that there are no conflicts of interest.

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Authors and Affiliations

  1. School of Science and Technology, University New England, Armidale, NSW, Australia

    Amanda D. Hagstrom

  2. School of Science and Health, Western Sydney University, Campbelltown, Australia

    Amanda D. Hagstrom, Paul W. M. Marshall, Shona Papalia, Birinder S. Cheema & Simon Green

  3. Institute for Positive Psychology and Education, Australian Catholic University, Strathfield, NSW, Australia

    Chris Lonsdale

  4. The National Institute of Complementary Medicine (NICM), Western Sydney University, Campbelltown, NSW, Australia

    Birinder S. Cheema

  5. School of Medicine, University of Adelaide, Adelaide, Australia

    Catherine Toben & Bernhard T. Baune

  6. Exercise, Health and Performance Research Group and Sydney Medical School, University of Sydney, Sydney, Australia

    Maria A. Fiatarone Singh

  7. Hebrew Senior-Life and Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, Boston, MA, USA

    Maria A. Fiatarone Singh

  8. School of Medicine, Western Sydney University, Campbelltown, Australia

    Simon Green

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  1. Amanda D. Hagstrom
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  9. Simon Green
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Correspondence to Amanda D. Hagstrom.

Additional information

Trial registration: Clinical Trials (ANZCTR #: 12612000346875).

URL: http://www.anzctr.org.au/trial_view.aspx?id=362296.

The University of Western Sydney Human Research Ethics Committee has approved all research procedures (Approval Number: H9427).

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Hagstrom, A.D., Marshall, P.W.M., Lonsdale, C. et al. The effect of resistance training on markers of immune function and inflammation in previously sedentary women recovering from breast cancer: a randomized controlled trial. Breast Cancer Res Treat 155, 471–482 (2016). https://doi.org/10.1007/s10549-016-3688-0

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