Our Comfort Inn & Suites^® Harrisonville hotel is conveniently located just off of highway 49 which connects our town to Kansas City. Our location makes this the perfect hotel for those who are taking a long road trip or are just looking for a place to stay as they escape from the big city. Our hotel offers all the amenities you might need, whether you’re a business traveler or on your way to visit family or friends. Get a good night’s sleep in our premium bedding and wake up refreshed.